Interleukin-12 and -23 blockade mitigates elastase-induced abdominal aortic aneurysm
نویسندگان
چکیده
منابع مشابه
Probucol nanostructured lipid carrier ameliorates elastase-induced abdominal aortic aneurysm in mice
Probucol (PB) is a drug commonly used for the treatment of hyperlipidemia and atherosclerosis. In our previous study, we have proved that PB can ameliorate abdominal aortic aneurysm (AAA) induced by elastase in mice through its anti-inflammatory and anti-oxidative effect. In this study, the water solubility and oral absorption of PB were improved by encapsulating PB into nanostructured lipid ca...
متن کاملMatricellular protein CCN3 mitigates abdominal aortic aneurysm.
Abdominal aortic aneurysm (AAA) is a major cause of morbidity and mortality; however, the mechanisms that are involved in disease initiation and progression are incompletely understood. Extracellular matrix proteins play an integral role in modulating vascular homeostasis in health and disease. Here, we determined that the expression of the matricellular protein CCN3 is strongly reduced in rode...
متن کاملDrug Therapy for Small Abdominal Aortic Aneurysm
Dear Editor,Abdominal aortic aneurysm is often asymptomatic, less recognized, and causes considerable mortality and morbidity, if missed. The incidence varies from country to country and the occurrence is influenced by modifiable (smoking, coronary heart disease, hypertension, dyslipidemia, and prolonged steroid therapy) and non-modifiable risk factors (increasing age, male gender, and positive...
متن کاملComplement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm.
BACKGROUND We previously established that neutrophils play a critical role in the development of experimental abdominal aortic aneurysm (AAA). The signal that initiates the influx of neutrophils to the aortic wall, however, remains unknown. In this study, we tested the hypothesis that complement participates in the development of AAA by providing the necessary chemotactic signal that recruits n...
متن کاملInterleukin-6 receptor pathways in abdominal aortic aneurysm
METHODS We conducted a systematic review and meta-analysis of studies reporting circulating IL-6 in AAA, and new investigations of the association between a common non-synonymous functional variant (Asp358Ala) in the IL-6R gene (IL6R) and AAA, followed the analysis of the variant both in vitro and in vivo. Inflammation may play a role in the development of abdominal aortic aneurysms (AAA). Inte...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-46909-y